3/31/2024 0 Comments Best anti stroke medicationWhile the gastro intestinal safety profiles of COX-2 inhibitors have improved, the cardio-nephrotoxic adverse effects are still significant. COX-2 plays more of a role in prostaglandin mediated pain and inflammation, while COX-1 plays some housekeeping role in the protection of gastric mucosa and in platelet hemostasis. These medications inhibit Cyclooxygenases (COXs) enzymes, which are rate-determining enzymes for prostaglandins and other prostanoids synthesis, such as thromboxanes.Ĭompared with Nonselective NSAIDs that inhibit both COX-1 and COX-2, COX-2 inhibitors (as known as coxibs) inhibit only COX-2 enzymes. In addition to their anti-inflammatory effect, NSAIDs have antipyrexic and analgesic properties. Approximately 7.3% of elderly patients over 60 years old filled at least one NSAID prescription in one year period. The prevalence of NSAID use in patients over 65 years old is as high as 96% in the general practice setting. They are responsible for approximately 5-10% of all medications prescribed each year. NSAIDs are one of the most commonly prescribed classes of medication for pain and inflammation.
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